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Researcher Questions Federal Guidelines For Seasonal And Swine Flu Vaccines
ScienceDaily (Aug. 24, 2009) — With the seasonal flu season approaching and uncertainty over whether swine flu will become more severe, new research published by Yale School of Public Health has found that more people are likely to avoid illness if vaccines are given out first to those most likely to transmit viruses, rather than to those at highest risk for complications. This research differs from current vaccination recommendations of the Centers for Disease Control (CDC) and the Advisory Committee on Immunization Practices (ACIP).
See also:
Health & Medicine
* Vaccines
* Influenza
Computers & Math
* Mathematical Modeling
* Computer Modeling
Science & Society
* Public Health
* Disaster Plan
Reference
* Flu vaccine
* Vaccination
* MMR vaccine
* HPV vaccine
The Yale study appears in the August 20 issue of the journal Science online at the Science Express website. It will be published in the print journal Science at a later date.
The ACIP currently recommends that groups at high risk for complications of swine flu (novel influenza A or H1N1) be given priority for vaccination. The CDC recommends the same for seasonal flu vaccination. High-risk groups include children younger than 5 years old, adults 65 years of age and older, pregnant women, and those suffering from pulmonary, cardiovascular and other disorders.
But the study by Alison P. Galvani, Ph.D., an associate professor in the division of Epidemiology of Microbial Diseases at Yale, suggests that vaccines targeted at groups more likely to transmit flu viruses, rather than those at highest risk of complications, would result in fewer infections and improved survival rates.
Galvani used mathematical models to measure outcomes based on deaths, years of life lost and economic costs. Strikingly, these models found that schoolchildren and their parents, generally in their 30s, are the best groups to vaccinate when even a modest amount of an effective vaccine is available, because schoolchildren are most responsible for transmission and their parents serve as bridges to the rest of the population. By targeting these two age groups, the study found, the remainder of the population is better protected.
"Our results illustrate the importance of considering transmission when allocating vaccines" said Galvani. The paper was co-authored by Jan Medlock of Clemson University.
The CDC expanded its seasonal flu vaccination recommendations in 2008 to include children up to 18 years old. Still, Galvani's study determined that previous, and new, guidelines for both swine and seasonal flu performed substantially worse than the optimal strategies that she and her group identified.
For example, using the ACIP's new vaccination policies for the swine flu, the study determined that ACIP recommendations would result in 1.3 million infections, 2,600 deaths, and $2.8 billion in economic impact. In contrast, Galvani's model resulted in 113,000 infections, 242 deaths, and $1.6 billion in cost.
Galvani said reducing CDC prioritization of children under age 5 and the elderly could significantly improve the CDC's recommendations.
"The optimal allocation of vaccines is paramount to minimizing mortality and morbidity in the population, particularly when there is a supply shortage," she said.
Journal reference:
1. Jan Medlock and Alison P. Galvani. Optimizing Influenza Vaccine Distribution. Science, 2009; DOI: 10.1126/science.1175570
Adapted from materials provided by Yale University.
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Researcher Questions Federal Guidelines For Seasonal And Swine Flu Vaccines
ScienceDaily (Aug. 24, 2009) — With the seasonal flu season approaching and uncertainty over whether swine flu will become more severe, new research published by Yale School of Public Health has found that more people are likely to avoid illness if vaccines are given out first to those most likely to transmit viruses, rather than to those at highest risk for complications. This research differs from current vaccination recommendations of the Centers for Disease Control (CDC) and the Advisory Committee on Immunization Practices (ACIP).
See also:
Health & Medicine
* Vaccines
* Influenza
Computers & Math
* Mathematical Modeling
* Computer Modeling
Science & Society
* Public Health
* Disaster Plan
Reference
* Flu vaccine
* Vaccination
* MMR vaccine
* HPV vaccine
The Yale study appears in the August 20 issue of the journal Science online at the Science Express website. It will be published in the print journal Science at a later date.
The ACIP currently recommends that groups at high risk for complications of swine flu (novel influenza A or H1N1) be given priority for vaccination. The CDC recommends the same for seasonal flu vaccination. High-risk groups include children younger than 5 years old, adults 65 years of age and older, pregnant women, and those suffering from pulmonary, cardiovascular and other disorders.
But the study by Alison P. Galvani, Ph.D., an associate professor in the division of Epidemiology of Microbial Diseases at Yale, suggests that vaccines targeted at groups more likely to transmit flu viruses, rather than those at highest risk of complications, would result in fewer infections and improved survival rates.
Galvani used mathematical models to measure outcomes based on deaths, years of life lost and economic costs. Strikingly, these models found that schoolchildren and their parents, generally in their 30s, are the best groups to vaccinate when even a modest amount of an effective vaccine is available, because schoolchildren are most responsible for transmission and their parents serve as bridges to the rest of the population. By targeting these two age groups, the study found, the remainder of the population is better protected.
"Our results illustrate the importance of considering transmission when allocating vaccines" said Galvani. The paper was co-authored by Jan Medlock of Clemson University.
The CDC expanded its seasonal flu vaccination recommendations in 2008 to include children up to 18 years old. Still, Galvani's study determined that previous, and new, guidelines for both swine and seasonal flu performed substantially worse than the optimal strategies that she and her group identified.
For example, using the ACIP's new vaccination policies for the swine flu, the study determined that ACIP recommendations would result in 1.3 million infections, 2,600 deaths, and $2.8 billion in economic impact. In contrast, Galvani's model resulted in 113,000 infections, 242 deaths, and $1.6 billion in cost.
Galvani said reducing CDC prioritization of children under age 5 and the elderly could significantly improve the CDC's recommendations.
"The optimal allocation of vaccines is paramount to minimizing mortality and morbidity in the population, particularly when there is a supply shortage," she said.
Journal reference:
1. Jan Medlock and Alison P. Galvani. Optimizing Influenza Vaccine Distribution. Science, 2009; DOI: 10.1126/science.1175570
Adapted from materials provided by Yale University.
Email or share this story:
| More
Need to cite this story in your essay, paper, or report? Use one of the following formats:
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MLA
Yale University (2009, August 24). Researcher Questions Federal Guidelines For Seasonal And Swine Flu Vaccines. ScienceDaily. Retrieved August 24, 2009, from http://www.sciencedaily.com /releases/2009/08/090820161140.htm
Ads by Google
Advertise here
Moartea microscopica
Un virus necrutator ameninta femeile. Afla mai mult!
www.informarehpv.ro
Swine Flu Realtime
Get the latest updates on infection, deaths and more.
www.ubalert.com
Int. Diabetes Monitor
A free online review journal on trends in clinical diabetes.
InternationalDiabetesMonitor.com
A new way to BEAT Autism
Latest research on great autism treatment now available for all
www.FreeAutismReport.com
Discrete Mathematics
Distance course, no tuition fee, -study at home! University of Gävle
www.hig.se/n
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Flu Pandemic Risk: Swine Flu Monitoring Needed For Farm Workers, Study Says (Feb. 15, 2008) — A new study recommends that workers on pig farms be monitored as part of influenza pandemic preparedness, after a child on a communal farm in Canada was diagnosed with swine flu in 2006. Though the ... > read more
Humans May Give Swine Flu To Pigs In New Twist To Pandemic (July 10, 2009) — The strain of influenza, A/H1N1, that is currently pandemic in humans has been shown to be infectious to pigs and to spread rapidly in a trial pig population. Researchers infected five pigs with the ... > read more
1918 Flu Resulted In Current Lineage Of H1N1 Swine Influenza Viruses (May 1, 2009) — In 1918 a human influenza virus known as the Spanish flu spread through the central United States while a swine respiratory disease occurred concurrently. Researchers have found that the virus ... > read more
Harvard Medical School Releases Special Health Report On Swine Flu (Apr. 28, 2009) — A new report from Harvard Medical School explains how and why the swine flu virus is threatening humans and describes what to do if the infection reaches your ... > read more
Swine Flu Outbreak Illuminated By Avian Flu Research (Apr. 30, 2009) — A new study suggests that the potential for an avian influenza virus to cause a human flu pandemic is greater than previously thought. Results also illustrate how the current swine flu outbreak ... > read more
Search ScienceDaily
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Find with keyword(s):
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Fighting H5N1 Bird Flu
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www.tcc-group.eu
HyStem-CSS
3D Stem Cell Culture Introductory Price of $200
www.glycosan.com
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