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Detecting Bias In The Reporting Of Clinical Trials
ScienceDaily (Aug. 20, 2009) — A study by researchers at the University of Leicester has revealed new ways to spot whether medical research has hidden biases.
See also:
Health & Medicine
* Today's Healthcare
* Health Policy
Computers & Math
* Statistics
* Hacking
Science & Society
* Public Health
* Racial Disparity
Reference
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* Placebo effect
Writing in the British Medical Journal, Santiago Moreno and his colleagues demonstrate how to spot 'publication bias' in the reporting of clinical trials which potentially form the basis of Government and NHS health policies. They also show what mathematical adjustments can be made to remove such unintended distortion of data.
Health policies are founded on 'clinical trials': experiments done in a laboratory or with groups of patients, which produce statistical results (because no two individuals are alike). Experimental results are published in medical journals after being thoroughly checked to ensure that all the methods used were fair and accurate – but 'publication bias' can affect what gets published.
For example, trials with negative results – showing that a treatment doesn't work – may be less likely to be published than those showing that it does. And this can create a distorted view of the treatment's effectiveness when policy-makers have to decide on whether it is worthwhile.
The University of Leicester researchers- examined two new methods of statistical analysis, using data on anti-depressant use available from the United States' Food and Drug Administration (FDA). The FDA's data is considered 'gold standard' – free from bias – so it can be used to check whether statistics collected from journals, when adjusted, provide a true picture.
Both methods investigated by the Leicester team proved effective in identifying and eliminating publication bias from medical research.
Santiago's colleagues in the research project were Professor Alex Sutton, Professor Keith Abrams and Dr Nicola Cooper, from the Department of Health Sciences, plus collaborators at the Universities of Bristol and Oregon.
Adapted from materials provided by University of Leicester, via EurekAlert!, a service of AAAS.
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University of Leicester (2009, August 20). Detecting Bias In The Reporting Of Clinical Trials. ScienceDaily. Retrieved August 24, 2009, from http://www.sciencedaily.com /releases/2009/08/090819110014.htm
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ScienceDaily: Your source for the latest research news and science breakthroughs -- updated daily
Science News
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Detecting Bias In The Reporting Of Clinical Trials
ScienceDaily (Aug. 20, 2009) — A study by researchers at the University of Leicester has revealed new ways to spot whether medical research has hidden biases.
See also:
Health & Medicine
* Today's Healthcare
* Health Policy
Computers & Math
* Statistics
* Hacking
Science & Society
* Public Health
* Racial Disparity
Reference
* Double blind
* Evidence-based medicine
* Clinical trial
* Placebo effect
Writing in the British Medical Journal, Santiago Moreno and his colleagues demonstrate how to spot 'publication bias' in the reporting of clinical trials which potentially form the basis of Government and NHS health policies. They also show what mathematical adjustments can be made to remove such unintended distortion of data.
Health policies are founded on 'clinical trials': experiments done in a laboratory or with groups of patients, which produce statistical results (because no two individuals are alike). Experimental results are published in medical journals after being thoroughly checked to ensure that all the methods used were fair and accurate – but 'publication bias' can affect what gets published.
For example, trials with negative results – showing that a treatment doesn't work – may be less likely to be published than those showing that it does. And this can create a distorted view of the treatment's effectiveness when policy-makers have to decide on whether it is worthwhile.
The University of Leicester researchers- examined two new methods of statistical analysis, using data on anti-depressant use available from the United States' Food and Drug Administration (FDA). The FDA's data is considered 'gold standard' – free from bias – so it can be used to check whether statistics collected from journals, when adjusted, provide a true picture.
Both methods investigated by the Leicester team proved effective in identifying and eliminating publication bias from medical research.
Santiago's colleagues in the research project were Professor Alex Sutton, Professor Keith Abrams and Dr Nicola Cooper, from the Department of Health Sciences, plus collaborators at the Universities of Bristol and Oregon.
Adapted from materials provided by University of Leicester, via EurekAlert!, a service of AAAS.
Email or share this story:
| More
Need to cite this story in your essay, paper, or report? Use one of the following formats:
APA
MLA
University of Leicester (2009, August 20). Detecting Bias In The Reporting Of Clinical Trials. ScienceDaily. Retrieved August 24, 2009, from http://www.sciencedaily.com /releases/2009/08/090819110014.htm
Ads by Google
Advertise here
Reimbursement Med. Device
Reimbursement for medical devices in Europe&Germany - we support you!
www.reimbursement.de
GSK Oncology
Oncology news for healthcare professionals. Read online now.
www.gskoncology.eu
Pericole sexuale
Lipsa de educatie sexuala poate duce la deces. Afla mai mult!
www.informarehpv.ro
Parkinson's Over 5 Years?
Stem cells therapy in China for age up to 60. From $30,000. Inquire now
www.StemCellsPuhua.com/_Contact_Us
Victoza® (liraglutide)
New injection now approved in EU for type 2 diabetes.
www.NovoNordisk.com
Related Stories
New Biosensor For Most Serious Form Of Listeria Food Poisoning Bacteria (May 1, 2009) — Scientists in Indiana are reporting development of a new biosensor for use in a faster, more sensitive test for detecting the deadliest strain of Listeria food poisoning bacteria. That microbe causes ... > read more
Half Of Trials Supporting FDA Applications Go Unpublished (Sep. 22, 2008) — Over half of all supporting trials for FDA-approved drugs remained unpublished 5 years after approval, says new research published in PLoS Medicine. The most important trials determining efficacy, ... > read more
Just How Useful Are Animal Studies To Human Health? (Dec. 18, 2006) — Animal studies are of limited usefulness to human health because they are of poor quality and their results often conflict with human trials, argue researchers in a study online in the British ... > read more
Use Of Some Antioxidant Supplements May Increase Mortality Risk (Feb. 28, 2007) — Contradicting claims of disease prevention, an analysis of previous studies indicates that the antioxidant supplements beta carotene, vitamin A and vitamin E may increase the risk of death, according ... > read more
Search ScienceDaily
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Acne Cure Exposed
10 Acne Cure Facts The Greedy Acne Industry Doesn't Want You To Know!
AcneCureExposed.net
Assign Group - CRO
We manage Clinical Trials from study set-up to final report
www.assigngroup.com
Clinical Trial Inspection
Replace your manual clinical trial label inspection with vision system
jli.dk
Just In:
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Using Light To Teach Magnets New Tricks
Microchip Does 1,000 Chemical Reactions At Once
Naming Evolution's Winners And Losers
Inner 'Fingerprint' For Personal Medical Care
Why Sleep? To Boost Efficiency, Minimize Risk
Ultrathin LEDs: New Class Of Displays
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Science Video News
HDTV for Colonoscopies
Gastroenterologists Use Hi-Res Narrow-Band Imaging To Find Cancer New optical technologies are helping gastroenterologists improve cancer detection. ... > full story
* Urologists Use Optics, Chemistry to Catch Small Tumors
* Computer Scientists Test Fatigued Driver Behavior
* Cancer Biologists Develop More Accurate Blood Test for Prostate Cancer
* more science videos
Breaking News
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* Encyclopedia of Life grows; clues on ageing, pests
* Satellites put into orbit for Japan and Australia
* Scientists make "sugar bug" drug for bowel disease
* Gene swap experiment makes altering bugs easier
* Mercury-tainted fish found widely in U.S. streams
* more science news
In Other News ...
* Malaysia state says woman to be caned after Ramadan
* U.S. presses sanctions to end N.Korea atomic plans
* Suspect in U.S. model murder found dead in Canada
* Justice Dept advises pursuing CIA abuses: report
* Singapore shoots down "rumor" of APEC attack plot
* Hurricane Bill kills 2 in U.S., drenches eastern Canada
* China trials over Xinjiang riot "likely this week"
* Warner Chilcott to buy P&G unit for $3 billion: sources
* more top news
Copyright Reuters 2008. See Restrictions.
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o ... more topics
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