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Pinhead-size Worms + Robot = New Antibiotics
ScienceDaily (Aug. 20, 2009) — In an advance that could help ease the antibiotic drought, scientists in Massachusetts are describing successful use of a test that enlists pinhead-sized worms in efforts to discover badly needed new antibiotics.
See also:
Health & Medicine
* Infectious Diseases
* Pharmacology
* HIV and AIDS
Plants & Animals
* Bacteria
* Microbes and More
* Microbiology
Reference
* Tularemia
* Forensic toxicology
* Antiviral drug
* Penicillin-like antibiotics
Frederick Ausubel and colleagues note in the new study that existing methods for identifying germ-fighting drugs involve adding the potential drug to cultures of bacteria or cells and watching the results. These tests sometimes do not work well. They may give passing grades to potential drugs that are toxic, or that fight bacteria in the same ways as existing antibiotics that are loosing effectiveness against drug-resistant bacteria.
A much better test would involve screening of potential new antibiotics in living animals infected with bacteria to see the effects on the entire body of the animal.
The scientists describe successful use of such a whole-animal high throughput screening test — automated with a robot — to test the effects of 37,000 potential drugs on C. elegans (a type of worm) infected with E. faecalis (a type of bacteria). That bacterium causes life-threatening infections in humans. C. elegans are tiny nematode worms that are widely used in scientific research.
The tests identified 28 potential new drugs never before reported to have germ-fighting effects. Some of the potential new drugs worked in ways that appeared to be totally different than existing antibiotics.
Journal reference:
1. Terence I. Moy, Annie L. Conery, Jonah Larkins-Ford, Gang Wu, Ralph Mazitschek, Gabriele Casadei, Kim Lewis, Anne E. Carpenter, Frederick M. Ausubel. High-Throughput Screen for Novel Antimicrobials using a Whole Animal Infection Model. ACS Chemical Biology, 2009 4 (7), 527-533 DOI: 10.1021/cb900084v
Adapted from materials provided by American Chemical Society.
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C. elegans. This pinhead-sized worm could play an important role in discovering and testing new antibiotics, researchers say. (Credit: Wikimedia Commons)
Related Stories
Think Twice Before Using Antibiotics For Acute Maxillary Sinusitis (Apr. 15, 2008) — Four out of five patients who are seen in primary care with simple sinusitis improved within two weeks even if they had not been given antibiotics. When antibiotics were given they speeded up ... > read more
First Experimental Evidence For Speedy Adaptation To Pesticides By Worm Species (Dec. 28, 2008) — Scientists in Portugal have shown that populations of the worm Caenhorabditis elegans become resistance to pesticides in 20 generations -- that is, in only 80 ... > read more
Don't Use Antibiotics For Runny Noses, Say Researchers (July 21, 2006) — Antibiotics should not be given to patients with acute purulent rhinitis (a runny nose with coloured discharge), a familiar feature of the common cold, concludes a study published on bmj.com ... > read more
Toward Improved Antibiotics Using Proteins From Marine Diatoms (Sep. 11, 2008) — Researchers in Florida are reporting an advance toward tapping the enormous potential of an emerging new group of antibiotics identical to certain germ-fighting proteins found in the human immune ... > read more
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Faster Flu Test
New flu tests can diagnose the flu in as little as 30 minutes, to cut down on needless antibiotic use, which can build up resistance and make some. ... > full story
* Biophysicists Grow Pretty Bacteria In Petri Dishes To Find Antibiotics
* With New Antibiotics, Pediatricians Fight Proxy War on Bugs
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Science News
Share Blog Cite
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Pinhead-size Worms + Robot = New Antibiotics
ScienceDaily (Aug. 20, 2009) — In an advance that could help ease the antibiotic drought, scientists in Massachusetts are describing successful use of a test that enlists pinhead-sized worms in efforts to discover badly needed new antibiotics.
See also:
Health & Medicine
* Infectious Diseases
* Pharmacology
* HIV and AIDS
Plants & Animals
* Bacteria
* Microbes and More
* Microbiology
Reference
* Tularemia
* Forensic toxicology
* Antiviral drug
* Penicillin-like antibiotics
Frederick Ausubel and colleagues note in the new study that existing methods for identifying germ-fighting drugs involve adding the potential drug to cultures of bacteria or cells and watching the results. These tests sometimes do not work well. They may give passing grades to potential drugs that are toxic, or that fight bacteria in the same ways as existing antibiotics that are loosing effectiveness against drug-resistant bacteria.
A much better test would involve screening of potential new antibiotics in living animals infected with bacteria to see the effects on the entire body of the animal.
The scientists describe successful use of such a whole-animal high throughput screening test — automated with a robot — to test the effects of 37,000 potential drugs on C. elegans (a type of worm) infected with E. faecalis (a type of bacteria). That bacterium causes life-threatening infections in humans. C. elegans are tiny nematode worms that are widely used in scientific research.
The tests identified 28 potential new drugs never before reported to have germ-fighting effects. Some of the potential new drugs worked in ways that appeared to be totally different than existing antibiotics.
Journal reference:
1. Terence I. Moy, Annie L. Conery, Jonah Larkins-Ford, Gang Wu, Ralph Mazitschek, Gabriele Casadei, Kim Lewis, Anne E. Carpenter, Frederick M. Ausubel. High-Throughput Screen for Novel Antimicrobials using a Whole Animal Infection Model. ACS Chemical Biology, 2009 4 (7), 527-533 DOI: 10.1021/cb900084v
Adapted from materials provided by American Chemical Society.
Email or share this story:
| More
Need to cite this story in your essay, paper, or report? Use one of the following formats:
APA
MLA
enlarge
C. elegans. This pinhead-sized worm could play an important role in discovering and testing new antibiotics, researchers say. (Credit: Wikimedia Commons)
Related Stories
Think Twice Before Using Antibiotics For Acute Maxillary Sinusitis (Apr. 15, 2008) — Four out of five patients who are seen in primary care with simple sinusitis improved within two weeks even if they had not been given antibiotics. When antibiotics were given they speeded up ... > read more
First Experimental Evidence For Speedy Adaptation To Pesticides By Worm Species (Dec. 28, 2008) — Scientists in Portugal have shown that populations of the worm Caenhorabditis elegans become resistance to pesticides in 20 generations -- that is, in only 80 ... > read more
Don't Use Antibiotics For Runny Noses, Say Researchers (July 21, 2006) — Antibiotics should not be given to patients with acute purulent rhinitis (a runny nose with coloured discharge), a familiar feature of the common cold, concludes a study published on bmj.com ... > read more
Toward Improved Antibiotics Using Proteins From Marine Diatoms (Sep. 11, 2008) — Researchers in Florida are reporting an advance toward tapping the enormous potential of an emerging new group of antibiotics identical to certain germ-fighting proteins found in the human immune ... > read more
Search ScienceDaily
Number of stories in archives: 44,032
Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily's archives for related news topics,
the latest news stories, reference articles, science videos, images, and books.
Just In:
Lightning's Mirror Image ... Only Much Bigger
Using Light To Teach Magnets New Tricks
Microchip Does 1,000 Chemical Reactions At Once
Naming Evolution's Winners And Losers
Inner 'Fingerprint' For Personal Medical Care
Why Sleep? To Boost Efficiency, Minimize Risk
Ultrathin LEDs: New Class Of Displays
Oxycholesterol: Greatest Heart Disease Risk?
Science Video News
Faster Flu Test
New flu tests can diagnose the flu in as little as 30 minutes, to cut down on needless antibiotic use, which can build up resistance and make some. ... > full story
* Biophysicists Grow Pretty Bacteria In Petri Dishes To Find Antibiotics
* With New Antibiotics, Pediatricians Fight Proxy War on Bugs
* Chemists Develop New Tool For Treating Rosacea
* more science videos
Breaking News
... from NewsDaily.com
* S.Korea seeks 4-year prison term for stem cell fraud
* Encyclopedia of Life grows; clues on ageing, pests
* Satellites put into orbit for Japan and Australia
* Scientists make "sugar bug" drug for bowel disease
* Gene swap experiment makes altering bugs easier
* more science news
In Other News ...
* Netanyahu sees talks with Palestinians in 2 months
* Storm Bill loses steam in North Atlantic
* Fires near Athens recede after 3-day inferno
* Malaysian state to cane woman after Ramadan
* Justice Dept advises pursuing CIA abuses: report
* Facebook to boost staff by 50% in 2009: report
* U.S. presses sanctions to end N.Korea atomic plans
* Singapore shoots down "rumor" of APEC attack plot
* more top news
Copyright Reuters 2008. See Restrictions.
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