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Breakthrough Uses Light To Manipulate Cell Movement
ScienceDaily (Aug. 20, 2009) — One of the biggest challenges in scientists' quest to develop new and better treatments for cancer is gaining a better understanding of how and why cancer spreads. Recent breakthroughs have uncovered how different cellular proteins are turned 'on' or 'off' at the molecular level, but much remains to be understood about how protein signaling influences cell behavior.
See also:
Plants & Animals
* Cell Biology
* Molecular Biology
* Genetics
Matter & Energy
* Biochemistry
* Optics
* Organic Chemistry
Reference
* Heat shock protein
* Natural killer cell
* Cell membrane
* Plant cell
A new technique developed by Klaus Hahn, Ph.D. and his colleagues uses light to manipulate the activity of a protein at precise times and places within a living cell, providing a new tool for scientists who study the fundamentals of protein function.
In a paper published today in the journal Nature, Hahn, who is the Thurman Professor of Pharmacology at the University of North Carolina at Chapel Hill and a member of UNC Lineberger Comprehensive Cancer Center, described the technique, which uses light to control protein behavior in cells and animals simply by shining light on the cells where they want the protein to be active.
"The technology has exciting applications in basic research – in many cases the same protein can be either cancer-producing or beneficial, depending on where in a cell it is activated. Now researchers can control where that happens and study this heretofore inaccessible level of cellular control," said Hahn.
"Because we first tested this new technology on a protein that initiates cell movement, we can now use light to control where and how cells move. This is quite valuable in studies where cell movement is the focus of the research, including embryonic development, nerve regeneration and cancer metastasis," he added.
The new technology is an advance over previous light-directed methods of cellular control that used toxic wavelengths of life, disrupted the cell membrane or could switch proteins 'on' but not 'off'.
The research in Hahn's lab was carried out by Yi Wu, PhD, research assistant professor of pharmacology, in collaboration with a team led by Brian Kuhlman, PhD, associate professor of biochemistry and biophysics at UNC and a team led by Ilme Schlichting, PhD at the Max Planck Institute for Medical Research in Heidelberg, Germany.
This research was supported by the National Institutes of Health.
Adapted from materials provided by University of North Carolina School of Medicine, via EurekAlert!, a service of AAAS.
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A photoactivatable protein enables control of cell movement in living cells. Activation of Rac in the red circle led to localized cell protrusion and translocation of the kinase PAK to the cell edge (right hand image, Pak in red). (Credit: Yi Wu, UNC-Chapel Hill)
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Breakthrough Uses Light To Manipulate Cell Movement
ScienceDaily (Aug. 20, 2009) — One of the biggest challenges in scientists' quest to develop new and better treatments for cancer is gaining a better understanding of how and why cancer spreads. Recent breakthroughs have uncovered how different cellular proteins are turned 'on' or 'off' at the molecular level, but much remains to be understood about how protein signaling influences cell behavior.
See also:
Plants & Animals
* Cell Biology
* Molecular Biology
* Genetics
Matter & Energy
* Biochemistry
* Optics
* Organic Chemistry
Reference
* Heat shock protein
* Natural killer cell
* Cell membrane
* Plant cell
A new technique developed by Klaus Hahn, Ph.D. and his colleagues uses light to manipulate the activity of a protein at precise times and places within a living cell, providing a new tool for scientists who study the fundamentals of protein function.
In a paper published today in the journal Nature, Hahn, who is the Thurman Professor of Pharmacology at the University of North Carolina at Chapel Hill and a member of UNC Lineberger Comprehensive Cancer Center, described the technique, which uses light to control protein behavior in cells and animals simply by shining light on the cells where they want the protein to be active.
"The technology has exciting applications in basic research – in many cases the same protein can be either cancer-producing or beneficial, depending on where in a cell it is activated. Now researchers can control where that happens and study this heretofore inaccessible level of cellular control," said Hahn.
"Because we first tested this new technology on a protein that initiates cell movement, we can now use light to control where and how cells move. This is quite valuable in studies where cell movement is the focus of the research, including embryonic development, nerve regeneration and cancer metastasis," he added.
The new technology is an advance over previous light-directed methods of cellular control that used toxic wavelengths of life, disrupted the cell membrane or could switch proteins 'on' but not 'off'.
The research in Hahn's lab was carried out by Yi Wu, PhD, research assistant professor of pharmacology, in collaboration with a team led by Brian Kuhlman, PhD, associate professor of biochemistry and biophysics at UNC and a team led by Ilme Schlichting, PhD at the Max Planck Institute for Medical Research in Heidelberg, Germany.
This research was supported by the National Institutes of Health.
Adapted from materials provided by University of North Carolina School of Medicine, via EurekAlert!, a service of AAAS.
Email or share this story:
| More
Need to cite this story in your essay, paper, or report? Use one of the following formats:
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enlarge
A photoactivatable protein enables control of cell movement in living cells. Activation of Rac in the red circle led to localized cell protrusion and translocation of the kinase PAK to the cell edge (right hand image, Pak in red). (Credit: Yi Wu, UNC-Chapel Hill)
Related Stories
Feel The Light: OLED With Touch Function (Oct. 19, 2008) — Organic light-emitting diodes (OLED) are one of the most promising lighting technology for future lighting solutions. The OLED technology is the first real area light source technology in history. It ... > read more
Algal Protein In Worm Neurons Allows Remote Control Of Behavior By Light (Dec. 31, 2005) — By introducing expression of a special green-algae gene into neurons of the tiny, transparent nematode C. elegans, researchers have been able to elicit specific behavioral responses by simply ... > read more
Simple Eyes Of Only Two Cells Guide Marine Zooplankton To The Light (Nov. 23, 2008) — Scientists now explain the remarkable ability of marine zooplankton to swim towards light. A new study reveals how simple eyes of only two cells, sense the direction of light and guide movement ... > read more
Scientists Use Light To Control Proteins (Oct. 17, 2008) — Scientists have discovered a way to use light to control certain proteins that catalyze biochemical reactions. This discovery is one of the first examples of someone successfully controlling the ... > read more
Search ScienceDaily
Number of stories in archives: 44,032
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Just In:
Lightning's Mirror Image ... Only Much Bigger
Using Light To Teach Magnets New Tricks
Microchip Does 1,000 Chemical Reactions At Once
Naming Evolution's Winners And Losers
Inner 'Fingerprint' For Personal Medical Care
Why Sleep? To Boost Efficiency, Minimize Risk
Ultrathin LEDs: New Class Of Displays
Oxycholesterol: Greatest Heart Disease Risk?
Science Video News
New Light Bulb
A new type of light bulb improves illumination conditions for reading. A chrome cap at its top directs light downwards, casting 40 percent more light. ... > full story
* Biochemists And Engineers Create Fast-acting Pathogen Sensor
* Neuroendocrinologists Unlock Chemical Trigger to Puberty
* Viral Immunologists Invent Speedy Virus Identification Technique
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* S.Korea seeks 4-year prison term for stem cell fraud
* Encyclopedia of Life grows; clues on ageing, pests
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* Scientists make "sugar bug" drug for bowel disease
* Gene swap experiment makes altering bugs easier
* more science news
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* Storm Bill loses steam in North Atlantic
* Fires near Athens recede after 3-day inferno
* Malaysian state to cane woman after Ramadan
* Justice Dept advises pursuing CIA abuses: report
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* U.S. presses sanctions to end N.Korea atomic plans
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